Section 1: Core Concepts
1. Which of the following best captures the difference between chronological and biological age?
2. What does 'squaring the curve' of healthspan mean?
3. In the lecture's software/hardware analogy, epigenetics is the ______ and DNA is the ______.
4. Why does the lecture warn against relying only on 'normal' reference ranges on a standard lab report?
5. According to the lab-decoding lecture, fasting insulin is often a better early warning than HbA1c because…
6. Why is ApoB considered a more accurate cardiovascular risk marker than LDL cholesterol alone?
7. The 12 Hallmarks of Aging framework, referenced from the López-Otín 2023 paper, is best described as…
8. In the Month 1 grouping of hallmarks, which category is described as 'your cellular power plants fading and the body becoming insulin resistant'?
Section 2: Applied Scenarios
9. A member gets her labs back. B12 is 220 pg/mL (flagged 'within normal'), Ferritin is 22 ng/mL, Vitamin D is 28 ng/mL. Based on Month 1's optimal targets, what is the most accurate reading?
10. A member's dashboard shows: HbA1c 5.7%, hs-CRP 3.1, grip strength normal, ApoB borderline. Based on the four Aging Phenotypes, which is the most fitting label?
11. A member is a 'Structural Ager' with low grip strength and joint pain. Based on the lecture's phenotype-to-Heptathlon mapping, which lever should they prioritize?
12. Which combination of behaviors most directly supports the 'Trash' hallmarks (proteostasis, autophagy, senescence)?
Section 3: Myth vs Fact
13. Myth or fact: 'Positive self-perceptions of aging have a larger effect on longevity than low cholesterol or low blood pressure.'
14. Myth or fact: 'A plant-based diet is automatically anti-aging, even if it's mostly refined pasta, cookies, and processed foods.'
15. Myth or fact: 'Lp(a) is highly responsive to diet — enough kale can normalize it.'
16. Myth or fact: 'Loneliness raises inflammatory markers to a degree comparable with smoking.'
Section 4: Healthspan Heptathlon Integration
17. Month 1 most directly builds the foundation for which lifelong practice?
18. Which set best represents the 'Big Rocks' Month 1 asks you to transfer into your workbook baseline?
19. Imagine your 90-year-old self reflecting on Month 1. Which combination of habits most plausibly carried you there?
Section 5: Application and Integration
20. A 55-year-old presents with chronological age 55 but a Horvath epigenetic clock estimate of 62, elevated hs-CRP, and normal glucose. Which framing from Month 1 best organizes the picture?
21. Levy's 2002 findings on age self-perception most directly support which practical move inside the Month 1 arc?
22. A client's labs show low B12 (240 pg/mL), borderline homocysteine, low grip strength, and a fasting glucose of 92. Using the four Aging Phenotypes framework, which is the most defensible primary phenotype read?
23. Which weekly plan best embodies Month 1's 'one lead domino' logic for someone whose phenotype read is inflammation-leaning?
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Evidence strength key
- 🟢Meta-analysis — pooled human RCT evidence
- 🔵Randomized controlled trial in humans
- 🟡Observational cohort or large-scale human study
- 🟣Expert review or consensus statement
- ⚪Mechanistic / preclinical evidence